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Role
of Microbial Burden in Etiology of Allergy and Asthma
Lancet 1999; 354 (suppl II): 1215
Respiratory
Sciences Center, University of Arizona, Tucson, Arizona, USA (Prof
F D Martinez MD); TVW Telethon Institute for Child Health Research,
Perth, Western Australia, and Department of Microbiology, University
of Western Australia (Prof P G Holt DSc)
The potential
sources for these signals include viral infections (notably, respiratory3,4,22)
and also commensals and pathogens within the gut flora.4,11,23
Probiotics
in primary prevention of atopic disease: a randomised placebo-controlled
trial Lancet 2001; 357: 1076-79
Departments
of Paediatrics (M Kalliomäki MD, P Kero MD, E Isolauri MD),
Biochemistry and Food Chemistry (S Salminen PhD), and Clinical Chemistry
(P Koskinen MD), University of Turku and Turku University Hospital;
and National Public Health Institute, Turku, Finland (H Arvilommi
MD)
Interpretations
Lactobacillus GG was effective in prevention of early atopic
disease in children at high risk. Thus, gut microflora might be
a hitherto unexplored source of natural immunomodulators and probiotics,
for prevention of atopic disease.
Lancet 2001; 357: 1076-79
Atopy in
children of families with an anthroposophic lifestyle
Department of Laboratory Medicine, Division of Clinical Immunology
(J S Alm MD, Prof A Scheynius MD), Karolinska Institute and Hospital;
and Division of Environmental Epidemiology, Institute of Environmental
Medicine, Karolinska Institute (Prof G Pershagen MD), Stockholm;
Vidar Clinic, Järna (J Swartz MD); and Sachs' Children's Hospital,
Stockholm (G Lilja MD, J S Alm), Sweden
People who follow
an anthroposophic way of life use antibiotics restrictively, have
few vaccinations, and their diet usually contains live lactobacilli,
which may affect the intestinal microflora.
Interpretation:
Prevalence of atopy is lower in children from anthroposophic families
than in children from other families. Lifestyle factors associated
with anthroposophy may lessen the risk of atopy in childhood.
Lancet1999; 353: 148588
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Potential
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Prevention or Disease
Quercetin
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